1.我国总体脑卒中终生发病风险为39.9%,位居全球首位,这意味着每5个大约会有2个人罹患卒中。 2.脑卒中经抢救50%至80%留有不同程度的致残后遗症,约有3/4患者丧失劳动能力,有16%长期卧床或住院。 3.我国脑血管病人出院后第一年的复发率是30%,第五年的复发率高达59%。 4.2018年我国居民因脑血管病致死比例超过20%,这意味着每5位死亡者中至少有1人死于脑卒中。
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① 通过旁分泌作用发挥免疫调节功能和减轻脑卒中后炎症;
② 定向分化为神经细胞和星形胶质细胞等,补充、替代因缺血受损的细胞。
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[2]中国人脑中风发病率世界第一 且有年轻化趋势.20190430.新华网
[3]《中国脑卒中防治报告2019》国家卫健委脑卒中防治工程委员会
[4]Wei L, Fraser JL, Lu ZY, et al. Transplantation of hypoxia preconditioned bone marrow mesenchymal stem cells enhances angiogenesis and neurogenesis after cerebral ischemia in rats.Neurobiol Dis, 2012, 46(3): 635-645.
[5]Sheikh AM, Yano S, Mitaki S, et al. A Mesenchymal stem cell line(B10) increases angiogenesis in a rat MCAO model. Exp Neurol,2019, 311: 182-193.
[6]Yavagal DR,Lin B,Raval AP,et al. Efficacy and dose-dependent safety of intra-arterial delivery of mesenchymal stem cells in a ro- dent stroke model[J]. PLoS One,2014,9( 5) : e93735.
[7]刘玉林,闵瑜,黄臻.骨髓间充质干细胞移植在缺血性脑卒中治疗中的应用研究进展[J].山东医药,2020,60(35):98-101.
[8]陈秋竹,李岭,解慧琪.不同类型干细胞在缺血性脑卒中治疗中的应用研究进展[J].中国修复重建外科杂志,2021,35(01):111-117.
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